Disorders of Granulocyte/Monocyte Function

Question 1

What three receptors are involved in granulocyte rolling and adherence?

Answer 1

Sialyl-Lewis carbohydrates, L-selectins, and beta-2-integrins (CD11b and CD18)

Question 2

Phagocytosis occurs through these receptors: _______.

Answer 2

Fc-gamma RI, Fc-gamma RII, Fc-gamma RIII, C3b, and CR-1

Question 3

Describe chronic granulomatous disease.

Answer 3

A syndrome in which patients have defects in enzymes that produce the ROS that destroy bacteria. Recurrent infections limit the lifespan of the patient.

Question 4

Acquired disorders of granulocyte function can result from _______.

Answer 4

diabetes, rheumatoid arthritis, trauma, and renal failure

Question 5

The autosomal recessive disease in which patients lack CD18 and cannot have neutrophils extravasate is called ______.

Answer 5

leukocyte adhesion deficiency I

Question 6

Leukocyte adhesion deficiency II is ______.

Answer 6

congenital lack of Sialyl-Lewis X

Question 7

Chediak-Hidashi is ________.

Answer 7

an autosomal recessive syndrome in which membranes cannot fuse; symptoms include recurrent skin infections, neurodegeneration, albinism

Question 8

Those with myeloperoxidase deficiency are _______.

Answer 8

generally healthy, but have some deficiency in fighting infections

Question 9

Defects of complement factors _______ are associated with SLE.

Answer 9

1q, 4, and 2