Disorders of Granulocyte/Monocyte Number Flashcards

1
Q

Monocytes are usually in the bloodstream for ______ days before moving into tissue.

A

3-5 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Describe a monocyte.

A

Kidney-shaped nucleus, larger than RBCs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Neurophils are in the bone marrow for _____ until being released in the blood, where it resides for ______.

A

10 - 14 days; 6 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Neutropenia is _______.

A

a decrease in the absolute neutrophil count (including bands and segmented polymorphonuclear leukocytes), below accepted norms for age and other considerations

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the range of normal for absolute neutrophil count?

A

1,000 - 3,000 / uL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the highest-risk stratification of neutropenia?

A

ANC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

The most common cause of neutropenia is ________.

A

infection-associated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

There are three mechanisms of secondary neutropenia causes: _________.

A

Immune (penicillin–acute); toxic (phenothiazine–chronic); and hypersensitivity (dilantin, phenobarbital–chronic)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the mechanism of alloimmune neutropenia?

A

Maternal antibodies cross-react with neonatal neutrophils, resulting in netropeniac infants that resolves 3-4 months after birth.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What three genetic situations can result in neutropenia?

A

Apoptosis of myeloid precursors associated with elastase (ELA-2), HAX-1, or other genes; rarely associated with G-CSF receptor defects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are aphthous ulcers?

A

Cancre sores

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

List some of the viruses that can cause neutropenia.

A

EBV, HIV, CMV, hepatitis, measles, and varicella

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is Kostmann syndrome?

A

Hereditary defect of neutrophil production (apoptosis of myelocyte precursors, defects in G-CSF gene)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Autoimmune neutropenia, in which antibodies attack neutrophils, is found in _____.

A

systemic lupus erythematosus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

How should neutropenia be treated?

A

Identify the source of infection (if fever is present) and treat with antibiotics; G-CSF can be given; remove toxins or drugs that might be causing neutropenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What stages are most of the granulocytes in, in terms of the body’s total reservoir?

A

Metamyelocyte, bands, and segmented

17
Q

There are two types of neutropenia: _______.

A

I). that in which bone marrow reserves are depleted (can be primary or secondary), and II). that in which bone marrow reserves are normal (usually secondary)

18
Q

Cyclic neutropenia is _______, while Shwachman-Diamond syndrome is ______.

A

autosomal dominant; autosomal recessive

19
Q

“Left-shift” refers to an increase in _______.

A

bands and segmented neutrophils

20
Q

List some of the categories of neutrophilia.

A

Increased production, increased release from marrow, reduced margination, and reduced egress from circulation

21
Q

List some of the categories of eosinophilia.

A

Allergic disorders, tumors, parasitic infections, dermatitis, gastrointestinal disorders, hereditary disorders, and others