Rheumatology Review Flashcards
List the joints involved in osteoarthritis.
Heberden’s and Bouchard’s nodes, 1st MCP, hips, knees, spine, 1st MTP
Sports do not raise your risk of __________.
osteoarthritis
Osteoarthritis can result from metabolic disorders, such as _________.
hemochromatosis, Wilson’s, and ochronosis
TIMPs are _________; they will be decreased in _________.
tissue-inhibitors of metalloproteinases; osteoarthritis
There are no systemic features in ____________.
osteoarthritis
Prostaglandins, NO, and interleukin-1 stimulate _______ in osteoarthritis.
MMPs
List the joint distribution of rheumatoid arthritis.
Symmetric involvement of the small joints (with the exception of the DIPs); hips and knees may be involved
HLA-DR is a type of _______.
MHC II
The strongest genetic correlation with rheumatoid arthritis is ________.
QKRAA (a part of the third hypervariable region of HLA-DR4 and HLA-DR1)
Rheumatoid factor is produced in the _______; it is found in ____ percent of those with RA, but it is not specific to RA.
synovium; 85
________ is a more sensitive and specific test for RA.
Anti-CCP
The major type of cell in the synovial fluid of those with RA is ______.
neutrophils
Gout is _________ birefrigent., while CPDD is __________ birefrigent.
negatively; positively
Lesch-Nyhan is ______ recessive.
X-linked
CPDD results from ____________.
defects in the ANKH that causes chondrocytes to pump PPi into the synovium
