Rheumatology Review Flashcards
List the joints involved in osteoarthritis.
Heberden’s and Bouchard’s nodes, 1st MCP, hips, knees, spine, 1st MTP
Sports do not raise your risk of __________.
osteoarthritis
Osteoarthritis can result from metabolic disorders, such as _________.
hemochromatosis, Wilson’s, and ochronosis
TIMPs are _________; they will be decreased in _________.
tissue-inhibitors of metalloproteinases; osteoarthritis
There are no systemic features in ____________.
osteoarthritis
Prostaglandins, NO, and interleukin-1 stimulate _______ in osteoarthritis.
MMPs
List the joint distribution of rheumatoid arthritis.
Symmetric involvement of the small joints (with the exception of the DIPs); hips and knees may be involved
HLA-DR is a type of _______.
MHC II
The strongest genetic correlation with rheumatoid arthritis is ________.
QKRAA (a part of the third hypervariable region of HLA-DR4 and HLA-DR1)
Rheumatoid factor is produced in the _______; it is found in ____ percent of those with RA, but it is not specific to RA.
synovium; 85
________ is a more sensitive and specific test for RA.
Anti-CCP
The major type of cell in the synovial fluid of those with RA is ______.
neutrophils
Gout is _________ birefrigent., while CPDD is __________ birefrigent.
negatively; positively
Lesch-Nyhan is ______ recessive.
X-linked
CPDD results from ____________.
defects in the ANKH that causes chondrocytes to pump PPi into the synovium
Will spondyloarthropathies have ANA or RF?
No! But they will have increased TNFalpha in their joints
Genetic association with SLE?
HLA-DR3 and C4 null allele
cANCA is found in __________, while pANCA is found in __________.
GPA/Wegener’s; microscopic polyangiitis
Polymyositis displays _______, while dermatomyositis displays ________.
CD8+; CD4+
