Rheumatoid Arthritis Flashcards
Rheumatoid arthritis is ______________.
a systemic, inflammatory, autoimmune disorder of unknown etiology that results predominantly in a peripheral, symmetric, inflammatory synovitis often leading to cartilage and bone destruction and joint deformities
RA is a disease of mostly ___________, but medium and large joints are sometimes affected.
small joints (except DIP)
RA often affects the ________ joint of the spine.
C1-C2
Rheumatoid factor is present in ______ percent of cases of RA.
85
Two non-articular conditions commonly found with RA are ___________.
anemia and hypergammaglobulinemia
_________ are highly specific to RA, but are only found in 70% of cases.
Anti-CCP antibodies (which react against peptides containing citrulline, a modified amino acid)
Arthrocentisis will reveal ________ in patients with RA.
WBCs > 2,000 /uL (mostly neutrophils) and low glucose and low complement
Extra-articular findings of RA can include __________.
fatigue, malaise, anorexia, weight loss, low-grade fever
The most common genetic marker of RA is ________.
HLA-DR4
Women have a(n) _________ incidence compared to men.
increased (2.5)
Type A cells are _________, while type B cells are _______.
macrophages; fibroblasts
Rheumatoid arthritis has a genetic correlation with _________.
QKRAA (the third hypervariable region)
TNF-alpha, IL-17, and IL-1 also stimulate ___________.
receptor activator of nuclear factor kappa-B ligand, which then activates osteoclasts
Rheumatoid factor is __________.
an antibody that recognizes the Fc region of IgG (most are IgM, but some can can IgG and IgA)
There are four main elements to treating rheumatoid arthritis: ________________.
NSAIDs, DMARDs, physical therapy, and surgery
