Immunohematology Flashcards
Red blood cell antigens are ________, that are found on _________.
glycolipids (lipids that cross the membrane with terminal carbohydrates that serve as antigens); all cells
O type people are less likely to develop ___________.
pancreatic cancer an thromboembolic disorders
The basic backbone of the RBC antigen is _________.
the “H” set of sugars (which type O people have)
People with Bombay blood reject _________.
all types of blood, even O
Isohemagglutinins are __________.
antibodies to different RBC surface antigens (usually IgM)
Rh proteins are autosomal ________.
dominant (so you only need one D to be RhD+)
Describe the direct Coombs test, related to hematology and blood donation.
You take the person’s blood, add anti-Fc antibody, and if the cells agglutinate then you know that that person is making IgG against their own RBCs.
Describe an indirect Coombs test.
You take the donor’s RBCs, add recipient plasma, wash the protein off, and then add anti-Fc antibody; if the cells agglutinate, then you know the recipient is making antibody to the donor’s RBC.
How does RhoGAM prevent hemolytic disease of the newborn in pregnancy?
RhoGAM is a monoclonal antibody that binds to Rh+ cells. If you give RhoGAM to an Rh- mother having an Rh+ baby, then whatever fetal cells cross into the mother’s bloodstream will be quickly opsonized and the mother will not develop memory cells to Rh factor.
