Osteoarthritis Flashcards
What is osteoarthritis?
A disorder characterized by destruction of cartilage and subsequent hypertrophy of bone; it is the end stage of all types of arthritis
Hypertrophic bony spurs are called _______.
osteophytes
Osteoarthritis symptoms typically _____ with rest.
improve
Enlarged PIPs are called ______; enlarged DIPs are called ______.
Bouchard’s nodes; Heberden’s nodes
Other than Bouchard’s and Heberden’s nodes, what bony deformities are suggestive of osteoarthritis?
(1) squaring of the 1st carpometacarpal joint; (2) genu varus; (3) hallux valgus – bunion; (4) cervical and lumbar spondylosis (a generic term for wearing down of the spinal disks)
Lab findings that point to osteoarthritis are _________.
negative crystals, normal viscosity, WBCs between 200 and 2,000, and normal glucose
Younger than 45, _______ predominate, while older than 45 _______ predominate.
men; women
Osteoarthritis primarily affects ________.
weight-bearing joints and joints that are highly used
Cartilage has no _____ and no ________.
vasculature; nerves
90% of the collagen in cartilage is ________.
type II
____ are major promoters of inflammation in osteoarthritis.
IL-1 and TNF alpha
IL-1 and TNF-alpha stimulate ________.
matrix metalloproteases
