Topic 73 - Communication among cells, Intracellular receptor signaling Flashcards
Words to include in communication among cells
- Hypothalamus
- Signaling regulation
- Central integrating role
- Intracellular communication
- Direct communication
- Gap junctions
- Ionic transportation
- Cytoplasm
- Contact communication
- Cell membrane
- Immune system
- Communication by secretion
- Immune system
- Nervous system
- Endocrine
- Paracrine
- Local chemical mediators
- Autocrine
- Neurotransmitted
- Synaptic transmission
- Neurotransmitters
- CNS
- Myoneural junction
- ANS
- Perpiheral junction
- Cytoskeletal communication
- Direct communication
Words to include in intracellular receptor signaling
- Cytoplasm
- Lipophilic hormones
- Cell membrane
- Cytoplasmic receptor
- Nucleus
- Receptor-ligand complex
- DNA segment
- HRE’s
- Protein (enzyme)
- Aldosterone
- N+/Na+ ATPase pump
- K+ secreting channel
- Na+ reabsorbing channel
- Protein synthesis
- Nuclear receptor
- Variable domain
- NH2
- DNA-binding domain
- Ligand binding domain
- -COOH (carboxyl terminal
- Variable domain
Aldosterone
- Regulator
- N-terminal
- Amino acid segments
- Hormone receptor complex (DBD)
- Promotor region
- Receptor DNA complex
Communication among cells
Which organ is most important in cell signaling regulation?
Hypothalamus
Due to central integrating role
Communication among cells
Name the different types of IC communication
- Direct communication
- Contact communication
- Communication by secretion
- Endocrine secretion
- Paracrine secretion
- Autocrine secretion
- Neurotransmitted secretion
- Cytoskeletal communication
Communication among cells
Direct communication
- Transporting substances via gap junctions
- This is ionic transportation between the cytoplasm of one cell to another (requires cells to be close)
Intracellular communication
Contact communication
- Information processing by molecules integrated in the cell membrane
- This is a typical method in the immune system (requires cells to be close)
Intracellular communication
Communication by secretion
- Secreting molecules between cells that are not so close
- Important for the function of both the immune and the nervous system
- Different types of secretion:
-
Endocrine secretion
- Specialized cells will secrete hormones that will reach the recipient cells through the bloodstream
-
Paracrine secretion
- Local chemical mediators that will be broken down, immobilized or taken up by cells close to the producer very quickly, therefore this secretion will not use the bloodstream for transport
-
Autrocrine secretion
- When the cells own signal will affect it, this is a type of paracrine effect
-
Neurotransmitted secretion
- When a synaptic transmission causes the cells to secrete neurotransmitters, this type of secretion can be found in the CNS (myoneural junction) and in the ANS (peripheral junctions)
-
Endocrine secretion
Intracellular communication
Cytoskeletal communication
Processing mechanical information that will influence the cell by the cytoskeletal system
IC receptor signaling
Receptors in the cytoplasm of the cell
- Lipophilic hormones can pass the cellular membrane and bind to cytoplasmic receptors
- Then they reach the nucleus and exert the effect
- The receptor-ligand complex is able to enter the nucleus, and the DNA-binding domain of receptor “finds” DNA segments, called HRE`s
- Then it activates the structure gene downstream to HRE and a biological response is initiated trough a protein (enzyme)
IC receptor signalis
Fine structure of the nuclear receptor
-
Variable domain
- NH2
- DNA-binding domain
-
Ligand binding domain
- -COOH (carboxyl terminal)
IC receptor signaling
Role of aldosterone
- Binds to regulator
- On the receptor the hormone binding site is close to carboxyl terminal
- When it enters the nucleus, a short segment of receptor complex close to N-terminal finds basis pair segments on DNA, they are called HRE
- HRE binds to few amino acid segments of the hormone receptor complex called DBD (DNA-binding domain??)
- The promotor region is activated by the receptor DNA complex
- Expression
Overview of receptor families