Thiazolidinedione

Question 1

M?

Answer 1

insulin sensitisers-lower blood glucose by activating PPARy receptors
Induces genes enhancing insulin action in skeletal muscle, adipose tissue and liver with more glucose uptake and usage peripherally and less hepatic gluconeogenesis
Don’t stimulate pancreatic insulin secretion

Question 2

I?

Answer 2

single agent in T2DM if overweight or metformin is not tolerated
Second agent-metformin or sulphonylurea where more control is needed
Third agent-alternative to insulin

Question 3

C?

Answer 3

HF, CVD, risk factors for bladder cancer, elderly, hepatic impairment, other antidiabetic drugs

Question 4

A?

Answer 4

GI upset, anaemia, dizziness, headaches, oedema, cardiac failure, bladder cancer, fractures, liver toxicity,