Anti-psychotics-1st gen

Question 1

M

Answer 1

Block post-synaptic D2 receptors
Mesolimbic bt midbrain and limbic system-anti-psychotic effect if blocked
Nigrostriatal pathway-substantia nigra with striatum of basal ganglia
Tuberohypophyseal pathway-bt hypothalamus and pituitary
CTZ-no n and v
sedative effect

Question 2

I

Answer 2

psychomotor agitation
Schizophrenia-SE’s of 2nd gen
bipolar disorder
N and V

Question 3

C

Answer 3

Elderly, dementia, PD, drugs prolonging QTc

Question 4

A

Answer 4

extrapyramidal effects, acute dystonic reactions, akathisia, neuroleptic malignant syndrome, tardive dyskinesia, drowsiness, QTc prolongation, arrhythmias, ED, hyperprolactinaemia