Clopidogrel

Question 1

M?

Answer 1

Prevents platelet aggregation by binding irreversibly to ADP in clotting cascade on surface of platelets p2Y12 receptor
Can work with aspirin

Question 2

I?

Answer 2

Treatment of Acute coronary Syndrome-prevents arterial thrombosis
Prevent occlusion of coronary artery stent
Long-term secondary prevention of thrombotic arterial events with CVS, cerebrovascular and peripheral arterial disease
Reduces risk of intracardiac thrombus and embolic stroke in AF where CI of warfarin or oral anti-coagulants

Question 3

C?

Answer 3

Bleeding
Surgery
Renal and hepatic impairment
Pro-drug-inhibited by ccp450 inhibitors-omeprazole, ciprofloxacin, erythromycin and anti-fungals and SSRIs
Use lansoprazole if taking PPI for gastroprotection
Anticoagulants/NSAIDS

Question 4

A?

Answer 4

Bleeding-serious if GI, intracranial or after surgery
GI upset-dyspepsia, abdominal pain and diarrhoea
Thrombocytopenia-rare