Sulphonylureas

Question 1

M?

Answer 1

Lower blood glucose by stimulating pancreatic insulin secretion by blocking ATP-K channels in B cells in islets of langerhans causing depolarisation and opening of VGCCs increasing IC calcium conc so insulin moves out of cells

Question 2

I?

Answer 2

T2DM-single agent to control glucose and use when metformin is not tolerated or if not controlled well

Question 3

C?

Answer 3

Hepatic impairment, renal impairment, hypoglycaemic agents, prednisolone, thiazide and loop diuretics

Question 4

A?

Answer 4

GI upset, N and V, hypoglycaemia, hepatic toxicity, hypersensitivity and argranulocytosis