Bendroflumethazide/thiazides

Question 1

Mechs of action?

Answer 1

Inhibit Na/Cl co-transporter at the distal convoluted tubule, so less sodium reabsorption and so water reabsorption
Fall in ECFV
Overtime-RAAS compensation but VD continues-not sure how

Question 2

Indications?

Answer 2

Alternative first line for hypertension if calcium channel blocker cannot be used
Add-on treatment for hypertension if not controlled by CCB, ACE inhibitors or ARB

Question 3

Contraindications?

Answer 3

o Existing hypokalaemia and hyponatremia
o Gout
o NSIADS-not low-dose aspirin
o Other drugs lowering potassium-loop

Question 4

Adverse effects?

Answer 4

o	Hyponatremia
o	Hypokalaemia
o	Cardiac arrhythmias
o	Increased plasma concentrations of glucose, LDL-cholesterol and triglycerides
o	Impotence