Anti-psychotics-2nd gen

Question 1

M

Answer 1

Block post-synaptic D2 receptors
Mesolimbic-runs bt midbrain and limbic system
Nigrostriatal-substantia nigra and corpus s of basal ganglia
Tuberohypophyseal connects hypothalamus with pituitary
Improved effect against treatment-resistant schizophrenia and lowers risk of extra-pyramidal signs
Higher affinity to 5HT receptors and looser binding to D2 receptors

Question 2

I

Answer 2

Psychomotor agitation
Schizophrenia when SE’s of 1st gen
Bipolar disorder-acute

Question 3

C

Answer 3

CVD, severe heart disease, neutropenia,QTc

Question 4

A

Answer 4

sedation, extrapyramidal effects, metabolic disturbance,QTc prolongation and arrhythmias, Risperidone effects dopaminergic transmission in tuberohypophyseal pathway so breast symptoms, sexual dysfunction, agranulocytosis and myocarditis