Angiotensin Receptor Blockers

Question 1

M?

Answer 1

Block action of angiotensin II on the AR1 receptor.
This prevents vasoconstriction and aldosterone release, reducing afterload and so blood pressure.
It also causes efferent glomerular arteriole dilatation, delaying the effects of CKD
It also limits sodium and water reabsorption so decreasing preload in heart failure.

Question 2

I?

Answer 2

Alternative to ACE inhibitors- no cough
Hypertension-1/2nd line
Chronic heart failure-first line
Ischaemic heart disease
Diabetic nephropathy and CKD-reduces proteinuria

Question 3

C?

Answer 3

Renal artery stenosis
AKI
Pregnancy/breastfeeding
CKD-high doses
NSAIDS
Potassium-elevating drugs
Diuretics

Question 4

A?

Answer 4

Hypotension
Hyperkalaemia
renal failure

Question 5

Administration?

Answer 5

Oral, anytime