azathioprine

Question 1

M

Answer 1

Azathioprine’s mechanism of action is not entirely understood but it may be related to inhibition of purine synthesis, along with inhibition of B and T cells.5

6-thioguanine triphosphate, a metabolite of azathioprine, modulates activation of rac1 when costimulated with CD28, inducing T cell apoptosis.5 This may be mediated through rac1’s action on mitogen-activated protein kinase, NF-kappaB

Question 2

I

Answer 2

Severe/remission of Crohn's disease
Remission of UC
RA
autoimmune conditions
post-transplant
Eczema
myasthenia gravis

Question 3

C

Answer 3

elderly, preg, HI, RI, reduced thiopurine methyltransferase activity

Question 4

A

Answer 4

bone marrow depression, infection, pancreatitis, anaemia, thrombocytopenia, hepatic, hypersensitivity