Aldosterone Antagonists

Question 1

M

Answer 1

o M-Competitively bind to the aldosterone receptor-increased sodium and potassium retention
• Binds to mineralocorticoid receptors-in the DCT that increase ENaC activity and so reabsorption of sodium and water

Question 2

I

Answer 2

I-Ascites and oedema due to liver cirrhosis-spironolactone is the first-line diuretic
o CHF-moderate or within 1 month of MI-adding to BB and ACEi
o Primary hyperaldosteronism before/instead of surgery

Question 3

C

Answer 3

C-severe renal impairment, hyperkalaemia, Addison’s, preg/breastfeeding, ACEi, ARB’s, potassium supplements

Question 4

A

Answer 4

A-hyperkalaemia, muscle weakness, arrhythmias and cardiac arrest, gynaecomastia, liver impairment, jaundice, Steven-Johnson syndrome