Metformin Flashcards
1
Q
M?
A
Biguanide-lowers blood glucose by increasing sensitivity to insulin
Decreases gluconeogenesis and glycogenolysis
increased glucose utilisation by skeletal muscle
decreases intestinal absorption
Does not use pancreatic stimulation of insulin production
Reduces weight gain
2
Q
I?
A
T2DM-first line
3
Q
C?
A
Renal impairment AKI hypoxia hepatic impairment acute/chronic alcohol overuse IV contrast media drugs causing renal impairment prednisolone and diuretics
4
Q
A?
A
GI upset-N and V, taste disturbance, anorexia and diarrhoea
lactic acidosis
5
Q
Administration?
A
Oral, after food
