Anti-fungals

Question 1

M-

Answer 1

Polyene-bind to ergosterol in cell membranes-kill or slow down growth
Imidazole and triazole-inhibit ergosterol synthesis-impaired cell membrane synthesis, cell growth and replication
Can get resistance-exclusion of ergosterol from membranes changes in enzymes or efflux pores

Question 2

I

Answer 2

Local fungal infections-orapharynx, vagina, skin-topical

Systemic-invasive or disseminated fungal infections

Question 3

C

Answer 3

liver diseases, renal impairment,ccp450 drugs, clopidogrel, QTc prolongating drugs preg-fluconazole

Question 4

A

Answer 4

irritation, GI upset, headache, hepatitis, hypersensitivity, toxicity, arrhythmias, anaphylaxis