Macrolides Flashcards
1
Q
M?
A
Inhibit bacterial protein synthesis
Bind to 50S SU of ribosome and block translocation
Bacteriostatic mechs-stops bacteria growth and helps the immune system in killing the bacteria
Erythromycin-Gram positive
Clarithromycin-Gram negative
2
Q
I?
A
Treat resp and skin/soft tissue infections as and alternative to penicillin when allergic
Severe pneumonia-added to penicillin-legionella and mycoplasma
Eradicates H.pylori-with PPI and amoxicillin/metronidazole
3
Q
C?
A
Hypersensitivity to macrolides,hepatic and renal impairment, drugs metabolised by P450 enzymes, drugs prolonging QT intervals
4
Q
A?
A
Irritant, N and V, abdominal pain and diarrhoea and thrombophlebitis
Allergy, anti-biotic-associated colitis, cholestatic jaundice, prolongation of QT interval and ototoxicity
