Aminoglycosides

Question 1

M?

Answer 1

M-Bind irreversibly to bacterial ribosomes (30S) and inhibit protein synthesis and are bactericidal (aminoglycoside)
Work against gram-negative bacteria, staph, mycobacteria
Enter cells via oxygen-dependent transport system-enhanced by penicillin as some bacteria have reduced permeability or have enzymes breaking them down.

Question 2

I?

Answer 2

I-Severe infections cause by gram negative aerobes
Severe sepsis
Pyelonephritis and complex UTI’s
Biliary and intra-abdominal sepsis
Endocarditis

Question 3

C?

Answer 3

C-Neonates, elderly, renal impairment, myasthenia gravis (IV), loop diuretics, vancomycin, ciclosporin, chemo, cephalosporins and vancomycin

Question 4

A?

Answer 4

A-nephrotoxicity and ototoxicity, C DIFF COLITIS, GI upset