Thiamine

Question 1

Generic/Trade Name

Thiamine

Answer 1

Thiamine

Question 2

Thiamine

Drug Classification:

Answer 2

Vitamin B1

Question 3

Thiamine

Mechanism of Action:

Answer 3

Converts pyruvic acid to acetyl coenzyme A, allowing for breakdown of glucose into ATP in the Krebs Cycle.

Question 4

Thiamine

Pharmacokinetics

Answer 4

Onset- Rapid
Peak- Varies
Duration- Varies
½ Life- N/A

Question 5

Thiamine

Indications & Contraindications

Answer 5

Indications:

Administer with D50 to severe alcoholics to prevent Wernicke’s encephalopathy and Korsakoff’s psychosis

Contraindications:

None in EMS

Question 6

Thiamine

Side Effects/Adverse Reactions:

Answer 6

Hypotension, cardiovascular collapse

Pulmonary edema

Sweating, restlessness,

nausea, allergic reaction

Question 7

Thiamine

Adult & Pedi Dose:

Answer 7

(ADULT) 50-100 mg IV over 5 min

(PEDI) 10-25 mg IV over 5 min

Question 8

Thiamine

Precautions:

Answer 8

Given prior to dextrose to facilitate uptake if both indicated

Question 9

Thiamine

Drug-Drug Interactions:

Answer 9

None in EMS