Metoclopramide (Reglan)

Question 1

Generic/Trade Name

Metoclopramide

Answer 1

Reglan

Question 2

Generic/Trade Name

Reglan

Answer 2

Metoclopramide

Question 3

Metoclopramide (Reglan)

Drug Classification:

Answer 3

Antiemetic

Question 4

Metoclopramide (Reglan)

Mechanism of Action:

Answer 4

Potent central and peripheral dopamine antagonist; sensitizes GI smooth muscle to acetylcholine by direct action leading to increased gastric emptying and intestinal transit without increased secretions

Question 5

Metoclopramide (Reglan)

Pharmacokinetics

Answer 5

Onset- 1-3 min IV, 10-15 min IM
Peak- 1-2 hr
Duration- 1-3 hr
½ Life- 2.5-6 hr

Question 6

Metoclopramide (Reglan)

Indications & Contraindications

Answer 6

Indications: Severe nausea and vomiting

Contraindications:

• Hypersensitivity or sulfa allergies
• GI hemorrhage
• Bowel obstruction or perforation

Question 7

Metoclopramide (Reglan)

Side Effects/Adverse Reactions:

Answer 7

Drowsiness, fatigue, sedation, mental depression

dizziness, HTN, hypotension,
tachycardia, bradycardia

diarrhea,

dystonic reaction (tree/monster)

Question 8

Metoclopramide (Reglan)

Adult & Pedi Dose:

Answer 8

(ADULT) 10-20 mg IM, 10 mg slow IV

(PEDI) 1-2 mg/kg/dose

Question 9

Metoclopramide (Reglan)

Precautions:

Answer 9

• Patients with CHF, hypokalemia, renal dysfunction
• dystonic reaction can occur have diphenhydramine available

Question 10

Metoclopramide (Reglan)

Drug-Drug Interactions:

Answer 10

• Antagonized by anticholinergics
• Potentiated effects with other CNS depressants