ACETAMINOPHEN (Tylenol®)

Question 1

Generic/Trade Name

ACETAMINOPHEN

Answer 1

Tylenol®

Question 2

Generic/Trade Name

Tylenol®

Answer 2

ACETAMINOPHEN

Question 3

ACETAMINOPHEN (Tylenol®)

Drug Classification:

Answer 3

Antipyretic

Analgesic

Question 4

ACETAMINOPHEN (Tylenol®)

Mechanism of Action:

Answer 4

COX inhibitor ⇒elevation of pain threshold, antipyretic by action on hypothalamic heat regulatory center

Question 5

ACETAMINOPHEN (Tylenol®)

Pharmacokinetics

Answer 5

• Onset of Action = 15-30 minutes
• Peak Effects = 30-120 minutes
• Duration of Effect = 3-4 hours
• Half-Life = 1-3 hours

Question 6

ACETAMINOPHEN (Tylenol®)

Indications & Contraindications

Answer 6

Indications/Field Use:
• Fever
• Mild-Moderate Pain

Contraindications:
• Hypersensitivity
• Patient with liver disease

Question 7

ACETAMINOPHEN (Tylenol®)

Side Effects/Adverse Reactions:

Answer 7

Dizziness, N+V

abdominal pain, hypoglycemia

Question 8

ACETAMINOPHEN (Tylenol®)

Adult & Pedi Dose:

Answer 8

(ADULT): 325-650mg PO q4-6h PRN, max dose 4g/day

(PEDI): 15mg/kg PO q4-6h PRN, max dose 4g/day

Question 9

ACETAMINOPHEN (Tylenol®)

Precautions:

Answer 9

Metabolized by liver – overdose can be toxic

Does not have anti-platelet aggregation effect

Does not have peripheral anti-inflammatory effect

Question 10

ACETAMINOPHEN (Tylenol®)

Drug-Drug Interactions:

Answer 10

Chronic excessive use of alcohol increases risk of hepatotoxicity