MORPHINE SULFATE

Question 1

Generic/Trade Name

MORPHINE SULFATE

Answer 1

MORPHINE SULFATE

Question 2

MORPHINE SULFATE

Drug Classification:

Answer 2

Narcotic Analgesic

Question 3

MORPHINE SULFATE

Mechanism of Action:

Answer 3

Opiate R agonist ⇒

• CNS depression
• Induces analgesia and sedation
• Increases peripheral venous capacitance and decreases venous return
• Decreases myocardial oxygen demand

Question 4

MORPHINE SULFATE

Pharmacokinetics

Answer 4

• Onset of Action = Immediate IV, 15-30 minutes IM
• Peak Effects = 20 minutes IV, 30-60 minutes IM
• Duration of Effect = 2-7 hours
• Half-Life = 1-7 hours

Question 5

MORPHINE SULFATE

Indications & Contraindications

Answer 5

Indications/Field Use:

• Severe pain/anxiety associated with MI
• Kidney stones
• Burns
• Pulmonary edema

Contraindications:

• Hypovolemia or hypotension
• Undiagnosed head injury / AMS
• Hypersensitivity to morphine, codeine, percodan
• COPD/compromised respiratory status

Question 6

MORPHINE SULFATE

Side Effects/Adverse Reactions:

Answer 6

AMS, N+V, HA

Blurred vision, constricted pupils

Respiratory depression

Abd. cramps,

Question 7

MORPHINE SULFATE

Adult & Pedi Dose:

Answer 7

(ADULT): 2-10mg IV initial, then 2mg every few min until relief of pain

(PEDI): 0.1mg/kg slow IVP (IO)

Question 8

MORPHINE SULFATE

Precautions:

Answer 8

Causes respiratory depression in high doses

have Narcan available

Question 9

MORPHINE SULFATE

Drug-Drug Interactions:

Answer 9

Additive effects (CNS depression) when given with:

• antihistamines
• antiemetics
• sedatives
• hypnotics
• barbiturates
• alcohol