ETOMIDATE (Amidate®)

Question 1

Generic/Trade Name

ETOMIDATE

Answer 1

Amidate®

Question 2

Generic/Trade Name

Amidate®

Answer 2

ETOMIDATE

Question 3

ETOMIDATE (Amidate®)

Drug Classification:

Answer 3

Sedative

Hypnotic

Question 4

ETOMIDATE (Amidate®)

Mechanism of Action:

Answer 4

Depresses reticular activating system (RAS) of the brain and potentiates GABA ⇒ causes sedation

Question 5

ETOMIDATE (Amidate®)

Pharmacokinetics

Answer 5

• Onset of Action = 10-20 seconds
• Peak Effects < 1 minute
• Duration of Effect = 3-5 minutes
• Half-Life = 30-70 minutes

Question 6

ETOMIDATE (Amidate®)

Indications & Contraindications

Answer 6

Indications/Field Use:
• Induction agent for RSI

Contraindications:
• Hypersensitivity

Question 7

ETOMIDATE (Amidate®)

Side Effects/Adverse Reactions:

Answer 7

Myoclonic skeletal muscle movement

apnea, hyperventilation, hypoventilation

laryngospasm

HTN, hypotension

tachycardia, bradycardia

N+V

Question 8

ETOMIDATE (Amidate®)

Adult & Pedi Dose:

Answer 8

(ADULT & PEDI): 0.1-0.3mg/kg IV, IO over 15-30 seconds

Question 9

ETOMIDATE (Amidate®)

Precautions:

Answer 9

Caution with hypotension, severe asthma, or severe cardiovascular disease

Question 10

ETOMIDATE (Amidate®)

Drug-Drug Interactions: