SUCCINYLCHOLINE (Anectine®)

Question 1

Generic/Trade Name

SUCCINYLCHOLINE

Answer 1

Anectine®

Question 2

Generic/Trade Name

Anectine®

Answer 2

SUCCINYLCHOLINE

Question 3

SUCCINYLCHOLINE (Anectine®)

Drug Classification:

Answer 3

Depolarizing neuromuscular blocker

Question 4

SUCCINYLCHOLINE (Anectine®)

Mechanism of Action:

Answer 4

Cholinergic R-agonist ⇒

• competes with ACh at neuromuscular junction
• when bound causes initial wave of widespread neuromuscular depolarization and prevents ACh binding and secondary muscle stimulation

Question 5

SUCCINYLCHOLINE (Anectine®)

Pharmacokinetics

Answer 5

• Onset of Action = 30-60 seconds IV, 2-3 minutes IM
• Peak Effects = 1-3 minutes
• Duration of Effect = 2-3 minutes IV, 10-30 minutes IM
• Half-Life = 5-10 minutes

Question 6

SUCCINYLCHOLINE (Anectine®)

Indications & Contraindications

Answer 6

Indications/Field Use:
• Need for temporary paralysis to facilitate endotracheal intubation and muscle tone or seizure activity prevent it

Contraindications:
• Penetrating eye injuries, narrow angle glaucoma
• Known or suspected hyperkalemia, Hx malignant hyperthermia

Question 7

SUCCINYLCHOLINE (Anectine®)

Side Effects/Adverse Reactions:

Answer 7

Wheezing, respiratory depression, apnea, aspiration

dysrhythmias, bradycardia, sinus arrest

HTN, hypotension,

increased intraocular pressure, increased ICP

Question 8

SUCCINYLCHOLINE (Anectine®)

Adult & Pedi Dose:

Answer 8

(ADULT): 1-2mg/kg IV, IO

(PEDI): 1mg/kg

Question 9

SUCCINYLCHOLINE (Anectine®)

Precautions:

Answer 9

May cause fractures in children because of muscle fasiculations

May cause dysrhythmias and cardiac arrest

Should be used by experienced providers, have rescue airways available

Question 10

SUCCINYLCHOLINE (Anectine®)

Drug-Drug Interactions:

Answer 10

Potentiated by:

• lidocaine
• procainamide
• β blockers
• magnesium sulfate
• other neuromuscular blockers