ROCURONIUM (Zemuron®)

Question 1

Generic/Trade Name

ROCURONIUM

Answer 1

Zemuron®

Question 2

Generic/Trade Name

Zemuron®

Answer 2

ROCURONIUM

Question 3

ROCURONIUM (Zemuron®)

Drug Classification:

Answer 3

Non-depolarizing neuromuscular blocker

Question 4

ROCURONIUM (Zemuron®)

Mechanism of Action:

Answer 4

Cholinergic R-antagonist ⇒ competes with ACh at neuromuscular junction and prevents binding so neuromuscular transmission is inhibited

Question 5

ROCURONIUM (Zemuron®)

Pharmacokinetics

Answer 5

• Onset of Action 30 – 60 seconds
• Peak Effects = 1-3 minutes
• Duration of Effect = 30-60 minutes
• Half-Life = 14-18 minutes

Question 6

ROCURONIUM (Zemuron®)

Indications & Contraindications

Answer 6

Indications/Field Use:
• Need for temporary paralysis to facilitate endotracheal intubation and muscle tone or seizure activity prevent it

Contraindications:
• Hypersensitivity

Question 7

ROCURONIUM (Zemuron®)

Side Effects/Adverse Reactions:

Answer 7

Bronchospasm (rarely)

Question 8

ROCURONIUM (Zemuron®)

Adult & Pedi Dose:

Answer 8

(ADULT): 0.6-1.2mg/kg IVP (IO)

(PEDI): 0.6mg/kg

Question 9

ROCURONIUM (Zemuron®)

Precautions:

Answer 9

Should be performed by skilled provider only, have rescue airway devices available and resuscitative equipment standing by

Question 10

ROCURONIUM (Zemuron®)

Drug-Drug Interactions: