Albuterol Sulfate (Proventil HFA, ProAir HFA)

Question 1

Generic/Trade Name

ALBUTEROL SULFATE

Answer 1

Proventil HFA®, ProAir HFA

Question 2

Generic/Trade Name

Proventil HFA®, ProAir HFA

Answer 2

ALBUTEROL SULFATE

Question 3

ALBUTEROL SULFATE (Proventil HFA®, ProAir HFA)

Drug Classification:

Answer 3

Sympathomimetic

Sympathetic agonist (β2 selective)

Question 4

ALBUTEROL SULFATE (Proventil HFA®, ProAir HFA)

Mechanism of Action:

Answer 4

β2 agonist ⇒ bronchodilation

Question 5

ALBUTEROL SULFATE (Proventil HFA®, ProAir HFA)

Pharmacokinetics

Answer 5

Onset of Action = 5-15 minutes

Peak Effects = 1.0-1.5 hours

Duration of Effect = 3-6 hours

Half-Life < 3 hours

Question 6

ALBUTEROL SULFATE (Proventil HFA®, ProAir HFA)

Indications & Contraindications

Answer 6

Indications/Field Use:
Asthma

Reversible bronchospasm associated with COPD

Contraindications:
Symptomatic tachycardia

Hypersensitivity

Question 7

ALBUTEROL SULFATE (Proventil HFA®, ProAir HFA)

Side Effects/Adverse Reactions:

Answer 7

Anxiety, HA, N+V

palpitations, sweating, dizziness, nervousness, tremor,

HTN, arrhythmias, chest pain

Question 8

ALBUTEROL SULFATE (Proventil HFA®, ProAir HFA)

Adult & Pedi Dose:

Answer 8

MDI: (ADULT) 1 or 2 sprays (90μg/spray)

Small-volume nebulizer: (ADULT) & (PEDI)

2.5mg in 2.5mL NS over 5-15 min

Question 9

ALBUTEROL SULFATE (Proventil HFA®, ProAir HFA)

Precautions:

Answer 9

• BP, pulse, and EKG should be monitored
• Caution w/ patients w/ known heart disease or HTN
• Auscultate LS pre/post treatment

Question 10

ALBUTEROL SULFATE (Proventil HFA®, ProAir HFA)

Drug-Drug Interactions:

Answer 10

• SE may increase with other sympathetic agonists
• β blockers may blunt effects
• MAOI and TCA may potentiate cardiovascular effects