MANNITOL (Osmotrol®)

Question 1

Generic/Trade Name

MANNITOL

Answer 1

Osmotrol®

Question 2

Generic/Trade Name

Osmotrol®

Answer 2

MANNITOL

Question 3

MANNITOL (Osmotrol®)

Drug Classification:

Answer 3

Osmotic diuretic

Question 4

MANNITOL (Osmotrol®)

Mechanism of Action:

Answer 4

Osmotic diuretic that inhibits sodium and water absorption in the kidneys and promotes fluid shift from intracellular to extracellular space

Question 5

MANNITOL (Osmotrol®)

Pharmacokinetics

Answer 5

• Onset of Action = 15 minutes
• Peak Effects = 3-8 hours
• Duration of Effect = Varies
• Half-Life = 100 minutes

Question 6

MANNITOL (Osmotrol®)

Indications & ContraindicationsMANNITOL (Osmotrol®)

Answer 6

Indications/Field Use:
• Acute cerebral edema
• Blood transfusion reactions

Contraindications:
Acute pulmonary edema, severe pulmonary congestion, hypovolemia

Question 7

MANNITOL (Osmotrol®)

Side Effects/Adverse Reactions:

Answer 7

Chills, HA, dizziness, lethargy, N+V

change in mental status, chest pain

Question 8

MANNITOL (Osmotrol®)

Adult & Pedi Dose:

Answer 8

(ADULT): 1.5-2g/kg IV, IO – slow bolus or infusion

(PEDI): 0.25-0.5g/kg IV over 60 min

Question 9

MANNITOL (Osmotrol®)

Precautions:

Answer 9

Rapid administration can cause transient volume overload and CHF

Diuresis can cause sodium depletion

Crystallization begins as temperature approaches 45ºF, always use in-line filter

Question 10

MANNITOL (Osmotrol®)

Drug-Drug Interactions:

Answer 10

Damages RBC’s, do not give with whole blood or
packed RBC’s