Ipatropium Bromide (Atrovent)

Question 1

Generic/Trade Name

IPRATROPIUM BROMIDE

Answer 1

Atrovent®

Question 2

Generic/Trade Name

Atrovent®

Answer 2

IPRATROPIUM BROMIDE

Question 3

IPRATROPIUM BROMIDE (Atrovent®)

Drug Classification:

Answer 3

Anticholinergic

Parasympatholytic

Question 4

IPRATROPIUM BROMIDE (Atrovent®)

Mechanism of Action:

Answer 4

Muscarinic ACh-R blocker ⇒ inhibits parasympathetic stimulation and vagally mediated responses by preventing increase in intracellular cGMP in bronchial smooth muscle⇒dries respiratory tract secretions and allows
for bronchodilation

Question 5

IPRATROPIUM BROMIDE (Atrovent®)

Pharmacokinetics

Answer 5

• Onset of Action = varies
• Peak Effects = 1.5-2.0 hours
• Duration of Effect = 4-6 hours
• Half-Life = 1.5-2.0 hours

Question 6

IPRATROPIUM BROMIDE (Atrovent®)

Indications & Contraindications

Answer 6

Indications/Field Use:

• Bronchial Asthma
• Reversible bronchospasm associated with COPD

Contraindications:

• Hypersensitivity
• Should not be used as primary acute treatment of bronchospasm

Question 7

IPRATROPIUM BROMIDE (Atrovent®)

Side Effects/Adverse Reactions:

Answer 7

Anxiety, HA, N+V, palpitations, dizziness, nervousness, rash

Question 8

IPRATROPIUM BROMIDE (Atrovent®)

Adult & Pedi Dose:

Answer 8

Small-volume nebulizer: (ADULT) 500μg –typically administered with a β agonist

Small-volume nebulizer: (PEDI) 250-500μg q20min PRN

Also available as MDI

Question 9

IPRATROPIUM BROMIDE (Atrovent®)

Precautions:

Answer 9

• BP, pulse, and EKG should be monitored
• Caution w/ patients w/ known heart disease or HTN and elderly
• Auscultate LS pre/post treatment

Question 10

IPRATROPIUM BROMIDE (Atrovent®)

Drug-Drug Interactions:

Answer 10

Few prehospitally, not specified