AMIODARONE HCL (Cordarone®)

Question 1

Generic/Trade Name

AMIODARONE HCL

Answer 1

Cordarone®

Question 2

Generic/Trade Name

Cordarone®

Answer 2

AMIODARONE HCL

Question 3

AMIODARONE HCL (Cordarone®)

Drug Classification:

Answer 3

Antidysrhythmic agent

Question 4

AMIODARONE HCL (Cordarone®)

Mechanism of Action:

Answer 4

• Class III Antiarrhythmic
• K+ channel blocker ⇒ Prolongs cardiac action potential duration and refractory period
• Demonstrates properties of Na+/Ca2+ channel blockers
• Noncompetitive inhibitor of α and β adrenergic receptors

Question 5

AMIODARONE HCL (Cordarone®)

Pharmacokinetics

Answer 5

• Onset of Action = Immediate
• Peak Effects = 30-45min
• Duration of Effect = Varies
• Half-Life = 40-55 days

Question 6

AMIODARONE HCL (Cordarone®)

Indications & Contraindications

Answer 6

Indications/Field Use:
• Cardiac Arrest (VF, Pulseless VT)
• Wide Complex Tachycardia

Contraindications:

• Cardiogenic shock
• severe sinus node dysfunction
• marked or symptomatic bradycardia
• 2º/3º Heart Block
• hypersensitivity

Question 7

AMIODARONE HCL (Cordarone®)

Side Effects/Adverse Reactions:

Answer 7

Hypotension, bradycardia,

dyspnea, cough, dizziness

Prolonged PR, QRS, QT intervals, increased ventricular beats

Question 8

AMIODARONE HCL (Cordarone®)

Adult & Pedi Dose:

Answer 8

• *VF/Pulseless VT (ADULT):** 300mg IV, IO, repeat dose 150mg IV, IO in 3-5min PRN
• *VT + Pulse (ADULT):** 150mg IV, IO over 10 min
• *Maintenance (ADULT):** 1mg/min first six hours, then 0.5mg/min
• *VF/Pulseless VT (PEDI):** 5mg/kg IV, IO; max dose 300mg, max total dose 15mg/kg
• *VT + Pulse (PEDI):** 5mg/kg IV, IO over 20-60 min; max dose 300mg

Question 9

AMIODARONE HCL (Cordarone®)

Precautions:

Answer 9

Caution patients with heart failure

Question 10

AMIODARONE HCL (Cordarone®)

Drug-Drug Interactions:

Answer 10

Warfarin, digoxin, procainamide, quinidine, phenytoin