OLANZAPINE (Zyprexa®)

Question 1

Generic/Trade Name

OLANZAPINE

Answer 1

Zyprexa®

Question 2

Generic/Trade Name

Zyprexa®

Answer 2

OLANZAPINE

Question 3

OLANZAPINE (Zyprexa®)

Drug Classification:

Answer 3

Antipsychotic

Question 4

OLANZAPINE (Zyprexa®)

Mechanism of Action:

Answer 4

SSRI, NE Reuptake inhibitor ⇒ antipsychotic and anticholinergic effects

Question 5

OLANZAPINE (Zyprexa®)

Pharmacokinetics

Answer 5

• Onset of Action < 30 minutes
• Peak Effects = 6 hours
• Duration of Effect = Varies
• Half-Life = 21-54 hours

Question 6

OLANZAPINE (Zyprexa®)

Indications & Contraindications

Answer 6

Indications/Field Use:
• Acute psychosis or agitation
• Alzheimer’s Disease

Contraindications:
• Hypersensitivity

Question 7

OLANZAPINE (Zyprexa®)

Side Effects/Adverse Reactions:

Answer 7

Myalgia (muscle pain), somnolence

dizziness, nausea, dry mouth

tremor, tachycardia, postural hypotension,

Question 8

OLANZAPINE (Zyprexa®)

Adult & Pedi Dose:

Answer 8

(ADULT): 10mg IM

(PEDI): Not Established

Question 9

OLANZAPINE (Zyprexa®)

Precautions:

Answer 9

Caution Pt with CV disease, predisposition for hypotension, and Parkinson’s disease

Must be reconstituted in 3mL sterile water prior to administration

Question 10

OLANZAPINE (Zyprexa®)

Drug-Drug Interactions:

Answer 10

Potentiates hypotensive effects of antihypertensives