ONDANSETRON (Zofran®)

Question 1

Generic/Trade Name

ONDANSETRON

Answer 1

Zofran®

Question 2

Generic/Trade Name

Zofran®

Answer 2

ONDANSETRON

Question 3

ONDANSETRON (Zofran®)

Drug Classification:

Answer 3

Antiemetic

Question 4

ONDANSETRON (Zofran®)

Mechanism of Action:

Answer 4

5-HT3 (serotonin) R antagonist ⇒ based on the theory that 5-HT3 receptors are present at the vagal nerve terminals and binding of serotonin initiates vomiting
reflex, Zofran would prevent this process.

Question 5

ONDANSETRON (Zofran®)

Pharmacokinetics

Answer 5

• Onset of Action = Est. 10-30 minutes
• Peak Effects = Unknown (theory)
• Duration of Effect = Unknown (theory)
• Half-Life = 4 hours

Question 6

ONDANSETRON (Zofran®)

Indications & Contraindications

Answer 6

Indications/Field Use:
• Nausea / Vomiting

Contraindications:
• Hypersensitivity

Question 7

ONDANSETRON (Zofran®)

Side Effects/Adverse Reactions:

Answer 7

HA, dizziness, dry mouth

tachycardia, chest pain, prolonged QT interval

constipation, diarrhea

Question 8

ONDANSETRON (Zofran®)

Adult & Pedi Dose:

Answer 8

(ADULT): 4mg slow IVP (IO) over 2-5 min

(PEDI): 0.1mg/kg slow IVP (IO) over 2-5 min

Question 9

ONDANSETRON (Zofran®)

Precautions:

Answer 9

Lower risk of sedation and dystonia than other antiemetics

Question 10

ONDANSETRON (Zofran®)

Drug-Drug Interactions:

Answer 10

May affect clearance and half-life with inducers and inhibitors of Cytochrome P-450 enzymes

(CYP3A4, CYP2D6, CYP1A2)

(WGAF?)