FENTANYL CITRATE (Sublimaze®)

Question 1

Generic/Trade Name

FENTANYL CITRATE

Answer 1

Sublimaze®

Question 2

Generic/Trade Name

Sublimaze®

Answer 2

FENTANYL CITRATE

Question 3

FENTANYL CITRATE (Sublimaze®)

Drug Classification:

Answer 3

Narcotic analgesic

Question 4

FENTANYL CITRATE (Sublimaze®)

Mechanism of Action:

Answer 4

μ opiate R-agonist ⇒ analgesia

Question 5

FENTANYL CITRATE (Sublimaze®)

Pharmacokinetics

Answer 5

• Onset of Action = Immediate
• Peak Effects = 3-5 minutes IV
• Duration of Effect = 30-60 minutes
• Half-Life = 6-8 hours

Question 6

FENTANYL CITRATE (Sublimaze®)

Indications & Contraindications

Answer 6

Indications/Field Use:
• Severe pain / Maintenance of analgesia
• Adjunct for RSI

Contraindications:
• Severe hemorrhage, shock
• Known hypersensitivity

Question 7

FENTANYL CITRATE (Sublimaze®)

Side Effects/Adverse Reactions:

Answer 7

Bradycardia, respiratory depression, apnea, chest wall rigidity

Question 8

FENTANYL CITRATE (Sublimaze®)

Adult & Pedi Dose:

Answer 8

(ADULT): 1μg/kg slow IV, IO, max single dose 100μg, repeat after 10 min

(PEDI): 1-2μg/kg slow IV, IO

Question 9

FENTANYL CITRATE (Sublimaze®)

Precautions:

Answer 9

Caution Pt with kidney and liver dysfunction

Halve the dose for elderly patients > 65yrs, repeat after 5 min

Question 10

FENTANYL CITRATE (Sublimaze®)

Drug-Drug Interactions:

Answer 10

Additive effects w/ CNS depressants

not for Pt who used MAOI w/in 14 days