MIDAZOLAM (Versed®)

Question 1

Generic/Trade Name

MIDAZOLAM

Answer 1

Versed®

Question 2

Generic/Trade Name

Versed®

Answer 2

MIDAZOLAM

Question 3

MIDAZOLAM (Versed®)

Drug Classification:

Answer 3

Anticonvulsant

Benzodiazepine

Sedative

Hypnotic

Question 4

MIDAZOLAM (Versed®)

Mechanism of Action:

Answer 4

Positive allosteric modulator for GABAA receptors ⇒Binds to benzo receptor site on chloride channels and potentiates binding and effects of GABA

(increasesintracellular Cl- concentration leading to hyperpolarization of the cell)

Question 5

MIDAZOLAM (Versed®)

Pharmacokinetics

Answer 5

Onset of Action = 3-5 minutes IV, 15 minutes IM

Peak Effects = 20-60 minutes

Duration of Effect < 2 hours IV, 1-6 hours IM

Half-Life = 1-4 hours

Question 6

MIDAZOLAM (Versed®)

Indications & Contraindications

Answer 6

Indications/Field Use:
• Pre-medication for cardioversion or TCP
• Sedation post-intubation
• Seizure

Contraindications:
• History of narrow-angle glaucoma
• Shock, depressed vitals, alcoholic coma

Question 7

MIDAZOLAM (Versed®)

Side Effects/Adverse Reactions:

Answer 7

Laryngospasm, bronchospasm

dyspnea, respiratory depression and arrest

drowsiness, amnesia, AMS

tachycardia, bradycardia, PVC’s,

retching

Question 8

MIDAZOLAM (Versed®)

Adult & Pedi Dose:

Answer 8

(ADULT): 2-5mg (0.5mg/kg) slow IV, IO, IM

(PEDI): 0.2mg/kg slow IV, max dose 10mg

Question 9

MIDAZOLAM (Versed®)

Precautions:

Answer 9

• Monitor vitals
• Have emergency resuscitative equipment available
• More potent than other benzos ⇒ increased risk of respiratory depression/arrest
• Have benzo antagonist available

Question 10

MIDAZOLAM (Versed®)

Drug-Drug Interactions:

Answer 10

Additive effects with CNS depressants and alcohol