ASPIRIN, ACETYLSALICYLIC ACID, ASA (Bayer®)

Question 1

Generic/Trade Name

ASPIRIN, ACETYLSALICYLIC ACID, ASA

Answer 1

Bayer®

Question 2

Generic/Trade Name

Bayer®

Answer 2

ASPIRIN, ACETYLSALICYLIC ACID, ASA

Question 3

ASPIRIN, ACETYLSALICYLIC ACID, ASA (Bayer®)

Drug Classification:

Answer 3

Platelet aggregation inhibitor

Anti-inflammatory

Salicylate

Question 4

ASPIRIN, ACETYLSALICYLIC ACID, ASA (Bayer®)

Mechanism of Action:

Answer 4

• Inhibits platelet aggregation by blocking the formation of Thromboxane A2 ⇒ which causes platelet aggregation and arterial constriction
• COX inhibitor ⇒ inhibits prostaglandin synthesis and reduces spread of inflammation

Question 5

ASPIRIN, ACETYLSALICYLIC ACID, ASA (Bayer®)

Pharmacokinetics

Answer 5

• Onset of Action = 5-30 minutes
• Peak Effects = 15-120 minutes
• Duration of Effect = 1-4 hours
• Half-Life = 15-20 minutes

Question 6

ASPIRIN, ACETYLSALICYLIC ACID, ASA (Bayer®)

Indications & Contraindications

Answer 6

Indications/Field Use:

• New chest pain suggestive of AMI/ACS

Contraindications:

• Hypersensitivity
• Relatively contraindicated w/ active ulcer disease and asthma

Question 7

ASPIRIN, ACETYLSALICYLIC ACID, ASA (Bayer®)

Side Effects/Adverse Reactions:

Answer 7

• GI bleeding
• wheezing
• N+V
• heartburn
• prolonged bleeding

Question 8

ASPIRIN, ACETYLSALICYLIC ACID, ASA (Bayer®)

Adult & Pedi Dose:

Answer 8

(ADULT) 160-325mg PO; 81mg Baby ASA preferred b/c can be chewed/swallowed

(PEDI) not recommended

Question 9

ASPIRIN, ACETYLSALICYLIC ACID, ASA (Bayer®)

Precautions:

Answer 9

(ADULT) 160-325mg PO; 81mg Baby ASA preferred b/c can be chewed/swallowed

(PEDI) not recommended

Question 10

ASPIRIN, ACETYLSALICYLIC ACID, ASA (Bayer®)

Drug-Drug Interactions:

Answer 10

ASA + other anti-inflammatory agents ⇒ increased side effects

ASA + antacid ⇒ decreased blood levels of drug b/c decreased absorption