RACEMIC EPINEPHRINE (Vaponephrine®)

Question 1

Generic/Trade Name

RACEMIC EPINEPHRINE

Answer 1

Vaponephrine®

Question 2

Generic/Trade Name

Vaponephrine®

Answer 2

RACEMIC EPINEPHRINE

Question 3

RACEMIC EPINEPHRINE (Vaponephrine®)

Drug Classification:

Answer 3

Sympathomimetic

Question 4

RACEMIC EPINEPHRINE (Vaponephrine®)

Mechanism of Action:

Answer 4

• α and β agonist, (slightly β2 selective) ⇒bronchodilation, decreased mucous membrane secretions, relieves subglottic edema

Question 5

RACEMIC EPINEPHRINE (Vaponephrine®)

Pharmacokinetics

Answer 5

• Onset of Action < 5 minutes inhaled
• Peak Effects = 5-15 min
• Duration of Effect = 1-3 hours
• Half-Life = N/A

Question 6

RACEMIC EPINEPHRINE (Vaponephrine®)

Indications & Contraindications

Answer 6

Indications/Field Use:
• Croup (Laryngotracheobronchitis)

Contraindications:
Hypertension, tachydysrhythmias, epiglottitis

Question 7

RACEMIC EPINEPHRINE (Vaponephrine®)

Side Effects/Adverse Reactions:

Answer 7

Restlessness, anxiety

dizziness, headache,N+V

hypertension, tachycardia

paradoxical bronchospasm

Question 8

RACEMIC EPINEPHRINE (Vaponephrine®)

Pedi Dose:

Answer 8

(PEDI) 5mg 1:1000 Epi in 2.5-3.0mL NS, nebulized with oxygen

– or –

0.25-0.75 of 2.25% solution in 2mL NS nebulized with oxygen

Question 9

RACEMIC EPINEPHRINE (Vaponephrine®)

Precautions:

Answer 9

rebound or worsened effects when med wears off

Question 10

RACEMIC EPINEPHRINE (Vaponephrine®)

Drug-Drug Interactions:

Answer 10

additive effects with other sympathomimetics