FUROSEMIDE (Lasix®) Flashcards
Generic/Trade Name
FUROSEMIDE
Lasix®
g
Lasix®
FUROSEMIDE
FUROSEMIDE (Lasix®)
Drug Classification:
Loop Diuretic
FUROSEMIDE (Lasix®)
Mechanism of Action:
Furosemide reversibly binds to chloride binding site on Na+/2Cl-/K+ cotransporter found on the luminal surface of the thick ascending limb of the loop of Henle ⇒ inhibits sodium and chloride reabsorption in the kidneys, thus impacting the osmotic gradient and reducing water reabsorption in the descending limb; causes venous dilation and subsequently reduces preload.
(Binds to Na+/2Cl-/K+ cotransporter in ascending limb of loop of Henle ⇒ inhibits Na+/2Cl-/K+ reabsorption impacting osmotic gradient and reducing water reabsorption in descending limb ⇒ causes venous dilation thereby reducing preload)
FUROSEMIDE (Lasix®)
Pharmacokinetics
- Onset of Action = 5-10 minutes vasodilation, 5-30 minutes, diuresis
- Peak Effects = 30 minutes vasodilation, 20-60 minutes diuresis
- Duration of Effect = 2 hours vasodilation, 6 hours diuresis
- Half-Life = 30 minutes
FUROSEMIDE (Lasix®)
Indications & Contraindications
Indications/Field Use:
• CHF
• Pulmonary Edema
Contraindications:
• Caution with sulfa allergies
• Caution with renal failure
• Pregnancy unless life threatening
FUROSEMIDE (Lasix®)
Side Effects/Adverse Reactions:
HA, dizziness, N+V
hypotension, dysrhythmias,
volume depletion, potassium depletion, diarrhea
FUROSEMIDE (Lasix®)
Adult & Pedi Dose:
(ADULT):
- 40mg slow IV, IO
- if Pt. takes Lasix daily incl. today, give their dose, if Pt.takes Lasix but didn’t today, double their dose
(PEDI): 0.5-1mg/kg slow IVP (not for children under 12)
FUROSEMIDE (Lasix®)
Precautions:
- Note LS and BP before and after treatment
- Protect from light
- May cause dehydration
FUROSEMIDE (Lasix®)
Drug-Drug Interactions:
- May cause additive effects and/or electrolyte imbalance if given with other diuretic
- NSAIDs may antagonize effects of Lasix
