METOPROLOL (Lopressor®)

Question 1

Generic/Trade Name

METOPROLOL

Answer 1

Lopressor®

Question 2

Generic/Trade Name

Lopressor®

Answer 2

METOPROLOL

Question 3

METOPROLOL (Lopressor®)

Drug Classification:

Answer 3

β Blocker

Question 4

METOPROLOL (Lopressor®)

Mechanism of Action:

Answer 4

β1 R-antagonist ⇒

negative inotropy (strength of contraction)

negative chronotropy (rate)

Question 5

METOPROLOL (Lopressor®)

Pharmacokinetics

Answer 5

• Onset of Action = Immediate
• Peak Effects = 20 minutes
• Duration of Effect = 13-19 hours (or 5-8hr?)
• Half-Life = 3-4 hours

Question 6

METOPROLOL (Lopressor®)

Indications & Contraindications

Answer 6

Indications/Field Use:
• SVT refractory to adenosine
• A-fib, a-flutter, stable narrow complex tachycardia

Contraindications:
• HR < 45 BPM, Systolic BP < 100mmHg
• CHF, any heart block, shock, asthma, bronchospasm

Question 7

METOPROLOL (Lopressor®)

Side Effects/Adverse Reactions:

Answer 7

CHF,Bradycardia, hypotension

dyspnea, wheezing

weakness, lethargy

Question 8

METOPROLOL (Lopressor®)

Adult & Pedi Dose:

Answer 8

(ADULT): 5mg slow IVP (IO) q 2-5min, max dose 15mg

(PEDI): not for pedi

Question 9

METOPROLOL (Lopressor®)

Precautions:

Answer 9

• Watch for onset CHF
• shock
• bronchospasm
• bradycardia
• heart block

Question 10

METOPROLOL (Lopressor®)

Drug-Drug Interactions:

Answer 10

Caution Pt.’s taking antihypertensives

Do not give to Pt. who has received IV
Verapamil (or other Ca2+ channel blocker?)