NALOXONE (Narcan®)

Question 1

Generic/Trade Name

NALOXONE

Answer 1

Narcan®

Question 2

Generic/Trade Name

Narcan®

Answer 2

NALOXONE

Question 3

NALOXONE (Narcan®)

Drug Classification:

Answer 3

Narcotic antagonist

Antidote

Question 4

NALOXONE (Narcan®)

Mechanism of Action:

Answer 4

Competitive opiate R antagonist ⇒ displaces narcotic molecules, has greater affinity for R site, but shorter duration

Question 5

NALOXONE (Narcan®)

Pharmacokinetics

Answer 5

• Onset of Action < 2 minutes IV, 2-10 minutes IM/ET
• Peak Effects < 2 minutes IV, 2-10 minutes IM/ET
• Duration of Effect = 20-120 minutes
• Half-Life = 60-90 minutes

Question 6

NALOXONE (Narcan®)

Indications & Contraindications

Answer 6

Indications/Field Use:
• Partial/complete reversal of respiratory depression caused by narcotics/opiates
• Coma of unknown origin
• R/O narcotic involvement in polypharmacy overdose prior to RSI

Contraindications:
• Hypersensitivity

Question 7

NALOXONE (Narcan®)

Side Effects/Adverse Reactions:

Answer 7

Hypotension, hypertension,

ventricular dysrhythmias

N+V, seizures

Question 8

NALOXONE (Narcan®)

Adult & Pedi Dose:

Answer 8

(ADULT): 0.4-2mg q2-3min IV, IO, IM, IN, ET – until respiratory status improves

(PEDI): 0.1mg/kg IM, max 2mg/dose

Question 9

NALOXONE (Narcan®)

Precautions:

Answer 9

Caution w/ Pt. potentially dependent on narcotics, may induce withdrawal – including newborn infants w/ addicted mothers

Question 10

NALOXONE (Narcan®)

Drug-Drug Interactions:

Answer 10

May induce withdrawal on narcotic dependent Pt.