ADENOSINE (Adenocard®) Flashcards
Generic/Trade Name
ADENOSINE
Adenocard®
Generic/Trade Name
Adenocard®
ADENOSINE
ADENOSINE (Adenocard®)
Drug Classification:
Antidysrhythmic (Class V)
Nucleoside
ADENOSINE (Adenocard®)
Mechanism of Action:
Adenosine (A1) R-agonist ⇒ Slows AV conduction by activation of G-protein second messengers, decreasing cAMP and inhibiting calcium entry into the pacemaker cells
(Slows AV conduction by inhibiting Ca2+ into pacemaker cells)
ADENOSINE (Adenocard®)
Pharmacokinetics
- Onset of Action = Immediate
- Peak Effects = Immediate
- Duration of Effect = 30-45 seconds
- Half-Life = 6 seconds
ADENOSINE (Adenocard®)
Indications & Contraindications
Indications/Field Use:
• SVT (PSVT) / Narrow Complex Tachycardia
• R/O SVT when diagnosing or assessing a rapid rhythm
• Wide complex tachycardia
Contraindications:
• 2°/3° Heart Block, Sick Sinus Syndrome
• Poison/chemical induced SVT (i.e. cocaine)
• Caution w/ asthma, bronchospasm, and unstable angina
• Torsades de Pointes (Polymorphic Ventricular Tachycardia)
ADENOSINE (Adenocard®)
Side Effects/Adverse Reactions:
Facial flushing, HA, dizziness
chest pain
ADENOSINE (Adenocard®)
Adult & Pedi Dose:
- *(ADULT):** 1st dose - 6mg rapid IVP followed by 20cc NS flush
- 2nd dose* - 12mg rapid IVP followed by 20cc NS flush
- 3rd dose* - 12mg rapid IVP followed by 20cc NS flush
- *(PEDI):** 1st dose - 0.1mg/kg IV/IO rapid push, max dose 6mg
- 2nd dose* - 0.2mg/kg IV/IO rapid push, max dose 12mg
ADENOSINE (Adenocard®)
Precautions:
- Begin printing rhythm strip before administering adenosine
- Give in A/C or higher (more proximal)
ADENOSINE (Adenocard®)
Drug-Drug Interactions:
- Methylxanthines (i.e. caffeine) are nonspecific competitive antagonists for
adenosine receptors – double the dose for Pt.’s taking large amounts - Carbamazepines (i.e. Tegretol, Phenobarbitol) potentiate effects of adenosine – halve the dose
