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(DIT) Rapid Fire + 4/5 Stars > Teratogens > Flashcards

Teratogens Flashcards

1
Q

ACEI and ARBs

A

renal failure, oligohydraminos

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2
Q

Aminoglycosides

A

ototoxicity

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3
Q

Fluoroquinolones

A

cartilage damage

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4
Q

Tetracyclines

A

discolored teeth

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5
Q

Cyclophosphamide

A

ear/facial anomalies
limb hypoplasia
absence of digits

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6
Q

Methotrexate

A

neural tube defects, abortion

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7
Q

Carbamazepine

A

neural tube defects - give folic acid supplements

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8
Q

Valproic acid

A

neural tube defects - give folic acid supplements

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9
Q

Phenytoin

A

fetal hydantoin syndrome

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10
Q

Lithium

A

Epstein anomaly

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11
Q

Statins

A

CNS and limb abnormalities

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12
Q

Warfarin

A

bone/cartilage defects, nasal hypoplasia

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13
Q

Isotretinoin

A

spontaneous aborption
heart and parathyroid defects
skin, CNS problems

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14
Q

Diethylstilbestrol (DES)

A

clear cell vaginal adenocarcinoma

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15
Q

Thalidomide

A

phocomelia - severe hypoplasia of limbs - flipper babies

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16
Q

Ionizing radiation

A

CNS malformations (early), malignancy (late)

17
Q

Excess Vit A

A

spontaneous abortion, microcephaly, cardiac defects

interfere w/ neural crest cell migration or HOX gene expression

18
Q

Maternal DM

A

cardiac defects, neural tube defects, caudal regression syndrome

19
Q

Maternal iodine deficiency

A

congenital hypothyroidism - cretinism

20
Q

Nicotine

A

placental abruption, low birth weight, IUGR

21
Q

Cocaine

A

Placental abruption, low birth weight, IUGR

22
Q

Alcohol

A

fetal alcohol syndrome:
Facial abnormalities - narrow eye openings, wide set eyes, smooth philtrum, thin upper lip, cleft palate

intellectual disability

microcephaly

Holoprosencephaly - cycloptic midline eye

(DIT) Rapid Fire + 4/5 Stars (162 decks)

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