Cancer genetic markers Flashcards
1
Q
K-RAS
A
Colon, pancreas, lung
2
Q
H-RAS
A
Bladder and kidney tumors
3
Q
N-RAS
A
Melanoma, hematologic malignancies, follicular thyroid cancer
4
Q
APC
A
Adenomatous polyposis coli
Familial adenomatoses polyposis -> colon cancer
5
Q
BRCA ½
A
BReast Cancer, ovarian cancer
6
Q
DPC (SMAD4)
A
Deleted in pancreatic cancer
7
Q
DCC
A
Deleted in colon cancer
8
Q
NF1
A
Chr 17 (17 letters) Neurofibromatosis type 1 (café au lait) Aka von Recklinghausen
9
Q
NF2
A
Chr 22
Neurofibromatosis type 2
b/l acoustic schwannoma
10
Q
WT1 and WT2
A
Wilms Tumor
Chr 11
“World Trade on nine 11”
11
Q
VHL
A
Von hippel-lindau Chr 3 (3 words)
12
Q
TSC
A
Tuberous sclerosis
13
Q
BCR-ABL
A
T(9;22) – Tyrosine kinase
Philadelphia chromosome
CML
Always on
14
Q
RET
A
Receptor protein
-> intracellular tyrosine kinase always on
MEN2A, 2B
-> pneochormocytoma, medullary thyroid cancer
papillary carcinoma of thyroid
15
Q
HER2/neu (ERBB2)
A
Breast, ovarian, gastric cancer
