Endocrine hormones Flashcards
1
Q
Hormones with cAMP second messenger
A
“FLAT” – FSH, LH, ACTH, TSH hCG MSH GHRH, CRH PTH, calcitonin Glucagon V2 vasopressin receptor
2
Q
Hormones with IP3 messenger
A
GnRH
TRH
Oxytocin
V1 vasopressin receptor
3
Q
Hormones with tyrosine kinase receptor
A
GH Prolactin Insulin Insulin-like growth factor Platelet derived growth factor Fibroblast growth factor Several cytokines
4
Q
cGMP second messenger
A
NO
ANP
Vasodilators
5
Q
Hormones w/ steroid receptors
A
Estrogens, progesterones, testosterone Glucocorticoids Aldosterone Thyroid hormone Vit D
6
Q
Steroid receptors
A
Intracellular – in cytoplasm
Bind and change conformation to bind DNA -> translocate to nucleus
Bind gene enhancer region
Regulate gene transcription
7
Q
Steroids in circulation
A
Binding globulins
Thyroid hormone – thyroid-binding globulin (TBG)
Sex hormones – sex hormone binding globulin (SHBG)
Increase SHBG -> decreased free T -> gynecomastia
Decrease SHBG -> increased free T
Male: no effect
Female -> hirsuitism
8
Q
Pregnancy effect on hormones
A
Increased binding globulin production
Impact thyroid hormone levels
