Drug Metabolism Flashcards
1
Q
P450 Inhibitors
A
“CRACKAMIGOS”
Ciprofloxacin Ritonavir (protease inhibitors) Amiodarone Cimetidine Ketoconazole Acute alcohol use Macrolides (erythromycin, clarithromycin) Isoniazid Grapefruit juice Omeprazole Sulfonamides
2
Q
P450 inducers
A
“Guinness, Coronas, PBRS lead to Chronic Alcoholism”
Griseofulvin Carbamazepine Phenytoin Barbiturates Rifampin St John Wort Chronic Alcoholism
3
Q
Phase I reactions
A
CYP450s
Hydrolysis
Oxidation
Reduction
Metabolites are polar, water soluble, active
Elderly lose phase I early
4
Q
Phase II reactions
A
Methylation
Acetylation (slow acetylators at risk for toxicity)
Glucuronidation
Sulfation
metabolites very polar, inactive, excrete in urine, not easily reabsorbed
5
Q
Draw out ethanol metabolism
A
page 144
6
Q
Zero Order drugs
A
“PEA”
Phenytoin, EtOH, Aspirin
