Cancer drugs – Antitumor Abx Flashcards
1
Q
Anthracyclines
A
Doxorubicin
Daunorubicin
Generate free radicals -> DNA damage
Intercalate DNA – wedge between base pairs
-> unable to unwind DNA
SE:
Cardiotoxic – dilated cardiomyopathy, HF
“Cardiotoxirubicin”
Heart susceptible to free radical damage d/t deficiency in superoxide dismutase
*Dexrazoxane to prevent cardiotoxicity
2
Q
Dactinomycin
A
intercalates DNA
“kids ACT WEiRd”
uses: - childhood tumors
Wilms tumor
Ewings sarcoma
Rhabdomyosarcoma
3
Q
Bleomycin
A
Binds to DNA -> ssDNA and dsDNA breaks
Generates free radicals
SE: pulmonary fibrosis
Tx: testicular cancer
4
Q
Testicular cancer treatment regime
A
“Eradicate Ball Cancer”
Bleomycin
Cisplatin
Etoposide
OR
Etoposide
Ifosfamide
Cisplatin
