Cancer drugs – Alkylating Agents

Question 1

Alkylating agents

Answer 1

Attaches alkyl group to DNA

Cross links DNA strand -> can’t replicate

Question 2

Cyclophophamide

Answer 2

Req bioactivation in liver

Alkylates guanine residues on DNA
Cancer
Immunosuppressant – lupus nephritis, polyarteritis nodosa

SE:
HEMORRHAGIC CYSTITIS
-d/t toxic metabolites – acrolein
prevented w/ mesna (bind acrolein)

increase risk transitional cell bladder cancer

Question 3

Ifosfamide

Answer 3

MOA and SE as cyclophosphamide

Testicular CA

Question 4

Nitrosoureas

Answer 4

Nitrogen mustards

-mustine

carmustine
lomustine
semustine

“Put Nitro in the Mustine, Carlose”

cross BBB
tx brain tumors
-> CNS toxicity

Question 5

Busulfan

Answer 5

Causes pulmonary fibrosis