Sleep disorders, insomnia, RLS, and narcolepsy Flashcards
What drugs can worsen insomnia?
What natural products can help with sleep?
What is short term insomnia treatment?
Alcohol, Bupropion, Caffeine, Decongestants, Diuretics, Fluoxetine if taken late in the day, steroids, stimulants, varenicline.
Melatonin or Valerian.
Benzos, LOT benzos in the elderly. OTC drugs are an option. EZ tip is Eszopiclone and Zolpidem for all 3 problems.
What drugs help with falling asleep?
What drugs help with staying asleep?
What drugs help with both?
Eszopiclone, Ramelteon, Zaleplon, Zolpidem.
Doxepin, Eszopiclone, Suvorexant, Zolpidem.
Eszopiclone and Zolpidem.
How do eszopiclone (lunesta) and Zolpidem work and what are their side effects?
How does Suvorexant (Belsomra) work?
What is the melatonin receptor agonist and its side effects?
Eszopiclone is lunesta and Zolpidem is Ambien, Ambien CR and Edluar and Intermezzo. They increase GABA at benzo receptors. Increased risk of CNS depression, potential for abuse and dependency, Somnolence, dizziness, ataxia, parasomnias, preferred over benzos.
Orexin receptor antagonist, blocks the orexin neuropeptide which promotes wakefulness.
Ramelteon (Rozerem) not a controlled substance, somnolence.
What is the antidepressant that helps with sleep?
What is primary drug treatment for restless leg syndrome?
How do you treat narcolepsy and it’s side effects?
Doxepin (Silenor), Trazodone may be used off label.
Dopamine agonists like pramipexole (mirapex) and ropinirole (requip). Rotigotine (Neupro) is a patch. Gabapentin can also help for PHN and RLS.
Stimulants like modafinil or xyrem (sodium oxybate). Rash in these can be life threatening.
What to know about Sodium Oxybate?
Derived from GABA and used with narcolepsy with cataplexy. C-3 for narcolepsy. This is a date rape drug. Restricted access through the Xyrem REMS program.
