Pulmonary Arterial Hypertension Flashcards
What select drugs can cause Pulmonary Arterial Hypertension?
What CCB’s are used in PAH?
What to know about epoprostenol(flolan)?
Cocaine, SSRI use during pregnancy.
Long acting nifedipine, diltiazem, and amlodipine.
Rebound PH warning, Chronic IV infusions can cause infections, vasodilation reactions, flushing, jaw pain, infusion site pain. Parenteral agents are most potent, avoid interruptions in therapy. Avoid large sudden dose reduction, must protect epoporstenol form light during infusion, flolan requires ice packs for stability,
What ot know about bosentan and ambrisentan?
What to know about PDE5’s?
What to know about riociguat?
CI’d in pregnancy due to embry fetal toxiciy, must have negative pregnancy test and monthly ther after. Hepatotoxicity, lower hgb/hct, fluid retention, headache. Bosentan can decrease the effectiveness of hormonal contraceptives.
Sildenafil(revatio or viagara), Tadalafil(adcirca or cialis), hearing loss, use with nitrates or riociguat CI’d, vision loss, NAION, priapism, hypotension, headache.
Sensitizes sCG and stimulate the receptor, negative pregnancy warning, hypotension, headache.
