Antibiotics 2 Flashcards
Do lipoglycopeptides have concentration dependent killing?
What are Televancin’s boxed warnings and warnings?
What to know about Oritavancin and Dalbavancin?
Yes
Fetal risk, nephrotoxicity. Can falsely increase coagulation tests and cause red man syndrome.
Oritavancin CI’d w/ use of IV UFH for 120 hours(5 days), same side effects as Televancin. Have extremely long half life allows for a single dose regimen.
What covers MRSA?
What covers Pseudomonas(CAMPFIRE)?
Which antibiotics do you NOT refrigerate?
Linezolid, Vancomoycin, Bactrim, Doxycycline and minocycline, Daptomycin.
Carbapenems, Aminoglycosides, monobactams, polymixins, Fluoroquinolones,Third and 4th generation cephalosporins, Piptazo(extended spectrum pen).
Cefdinir. Ciprofloxacin, Levofloxacin, Azithromycin and Clarithromycin, Bactrim, Clinda, Doxy
Can you use daptomycin to treat pneumonia?
What warnings to know about daptomycin?
What special things to know about Linezolid?
NO
Myopathy and rhabdomyolsis, Can falsely raise coagulation tests, CPK level weekly. Cubicin RF is not good with LR.
Avoid tyramine containing foods and serotonergic drugs(reversible MAOI), optic neuropathy, myleosuppresion(thrombocytopenia), do not SHAKE.
What to know about Quinupristin/Dalfopristin?
What to know about Tigecycline?
What to know about Colistimethate sodium and can polymixin B cause respiratory paralysis from neuromuscular blockade?
Not well tolerated, can’t use with E.faecalis. Watch for arthalgias/myalgias, infusion reactions, hyperbilirubinemia, dilue in D5W only, administer via a central line(PICC).
Increased risk of death boxed warning, do not use for bloodstream infections, reconstituted solution should be yellow-orange and if it’s not discard.
Dose dependant nephrotoxicity, neurotoxicity, prodrug, assess dose carefully, can be inhaled. YES, same side effects as Colistimethate.
Which antibiotic can cause Gray syndrome?
What is the boxed warning of Clindamycin?
What are the warnings of metronidazole, tinidazole and secnidazole?
Chloramphenicol
Colitis(c.dif), can also cause N/V/D. No renal adjustment, an induction test should be performed on s.aureus, flattened zone indicates clindamycin resistance .
CI’d in pregnancy(1st trimester), disulfiram reaction( 3 day window), metallic taste, Vulvovaginal candidiasis. 1:1 and secnidazole is a single dose.
Is fidaxomicin(dificid) or Rifaximin used for systemic infections?
When is Fosfomycin used?
What to know about Nitrofurantoin?
NO.
Single dose UTI
Used only for Uncomplicated UTI, Can’t use in Renal Impairment(CrCl <60). Watch for hemolytic anemia(positive coombs test), Dosing is 100 mg BID for 5 days, Caution in G6PD deficiency, Side effects are GI upset(take with food), and brown urine discoloration.
Which drugs don’t require renal adjustment?
Which drugs require light protection during administration?
Which drugs are compatible with dextrose only vs saline only?
Dicloxacillin, Nafcillin, Ceftriaxone, Clindamycin, Doxycycline, Macrolides(azithro and erythro), Metronidazole, Moxifloxacin, Linezolid.
Doxycycline, Micafungin
Dextrose–> Quinuspristin/Dalfopristin. Bactrim. Ampho B. Saline–> Ampicillin, Ampicillin/Sulbactam, Ertapenem.
What is the preferred antibiotic for perioperative prophylaxis?
What is meningitis treatment?
Cefazolin for colorectal surgery it’s cefotetan or cefoxitin.
Ceftriaxone or Cefotaxime + Vancomycin, Add Ampicillin in <1 month and >50 or immunocompromised for listeria coverage. NO Ceftriaxone in neonates due to biliary sludging. If severe pcn allergy use quinolone +vancomycin.
